Anti-LINGO1 antibody

Anti-LINGO1 antibody

Cat. No.     JLC163052
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-LINGO1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human LINGO1
Reactivity                 Human, Mouse
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification



Target information
Symbol                 LINGO1
Full name                 leucine rich repeat and Ig domain containing 1
Synonyms    LERN1; LRRN6A; UNQ201
Swissprot    Q96FE5

Target Background
Lingo-1 is a 614-amino acid protein that plays an important role in the negative regulation of myelination by oligodendrocytes in the central nervous system (CNS). Lingo-1 is a nervous system-specific transmembrane protein that interacts with NgR1 and p75 to make up a receptor complex that binds to Nogo, a protein that inhibits axonal regeneration. Reduction of Lingo-1 activity downregulates RhoA (a protein related to cytoskeleton regulation) activity, promotes oligodendrocyte differentiation, and increases axonal myelination in neuronal tissues. Conversely, overexpression of Lingo-1 activates RhoA and inhibits oligodendrocyte differentiation and myelination. Lingo-1 up-regulation may be a characteristic of activity-induced neural plasticity responses. Lingo-1 may be a critical deterrent of myelin and nerve fiber repair in multiple sclerosis, an inflammatory disease that causes gradual destruction of myelin in the CNS.