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FITC标记的真核翻译起始因子4E抗体

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  • ¥2980
  • LMAI Bio
  • LM-4979R-FITC
  • 中国/美国/欧洲
  • 2025年07月13日
  • ICC=1:50-200 IF=1:50-200
  • Human, Mouse, Rat,
  • Human, Mouse, Rat,
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上海联迈生物工程有限公司
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商：

      上海联迈生物工程有限公司

    • 库存：

      大量

    • 靶点：

      详见说明书

    • 级别：

      1

    • 目录编号：

      LM-4979R-FITC

    • 克隆性：

      多克隆

    • 抗原来源：

      Rabbit

    • 保质期：

      1年

    • 抗体英文名：

      Anti-eIF4E/FITC

    • 抗体名：

      Anti-eIF4E/FITC

    • 标记物：

      FITC标记

    • 宿主：

      Human, Mouse, Rat,

    • 适应物种：

      Human, Mouse, Rat,

    • 免疫原：

      详见说明书

    • 亚型：

      IGg

    • 形态：

      粉末、液体、冻干粉

    • 应用范围：

      ICC=1:50-200 IF=1:50-200

    • 浓度：

      1mg/ml

    • 保存条件：

      -20 °C

    • 规格：

      100ul

    FITC标记的真核翻译起始因子4E抗体
    英文名称 Anti-eIF4E/FITC
    中文名称 FITC标记的真核翻译起始因子4E抗体
    别    名 EIF4F; eIF-4E; eIF 4E; CBP; eIF 4F 25 kDa subunit; CBP; eIF 4E; eIF 4F 25 kDa subunit; EIF 4F; EIF4E1; EIF4EL1; EIF4F; Eukaryotic Translation Initiation Factor 4 E; Eukaryotic translation initiation factor 4E like 1; Messanger RNA Cap Binding Protein eIF 4E.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    研究领域 肿瘤  细胞生物  信号转导  转录调节因子  表观遗传学  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, 
    产品应用 ICC=1:50-200 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 24kDa
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human eIF4E
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk. 

    Function:
    Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. 

    Subunit:
    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1 (By similarity). Interacts with Lassa virus Z protein. Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. 

    Subcellular Location:
    Cytoplasm, P-body.

    Post-translational modifications:
    Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex. 

    Similarity:
    Belongs to the eukaryotic initiation factor 4E family.

    Database links:

    Entrez Gene: 1977 Human
    Entrez Gene: 13684 Mouse
    Entrez Gene: 117045 Rat
    Omim: 133440 Human
    SwissProt: P06730 Human
    SwissProt: P63073 Mouse
    SwissProt: P63074 Rat
    Unigene: 249718 Human
    Unigene: 3941 Mouse
    Unigene: 11275 Rat





    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    核细胞翻译起始因子4E-EIF4E是蛋白合成的一个主要调控因子，它表达量增加会促进多种肿瘤的生长的增值、分化，因此EIF4E是一种非常重要的抗癌药物靶标。eIF-4E是一种涉及核糖体与mRNA帽子结构结合的真核生物翻译起始因子。它以2种形式存在：游离形式（25kDa）和作为多蛋白复合物eIF-4F的一个组分。 eIF-4E 是数量最少的一种起始因子，涉及翻译起始的限速步骤，磷酸化调节蛋白质的生物合成。

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