- 询价
- gelatins
- JLC225573
- 上海
- 2025年07月15日
- Rabbit
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- 详细信息
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
大量
- 克隆性：
多克隆
- 保质期：
1年
- 抗体英文名：
Anti-PNRC2 antibody
- 宿主：
Rabbit
- 浓度：
0.54 mg/ml
- 保存条件：
-20°C
- 规格：
25 μl/100 μl/200 μl
Anti-PNRC2 antibody
Cat. No. JLC225573
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-PNRC2 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human PNRC2
Reactivity Human, Mouse, Rat
Content 0.54 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol PNRC2
Full name proline rich nuclear receptor coactivator 2
Synonyms
Swissprot Q9NPJ4
Target Background
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 30-150 Predicted cell location: Cytoplasm and Nucleus
Positive control: Human liver cancer
Recommended dilution: 30-150
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml225573(PNRC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml225573(PNRC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
ELISA
Recommended dilution: 5000-10000
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Anti-PNRC2 antibody
询价
