Anti-ADRA1A/FITC抗体

Anti-ADRA1A/FITC抗体

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  • ¥2980
  • LMAI Bio
  • LM-0600R-FITC
  • 中国/美国/欧洲
  • 2025年07月02日
  • Flow-Cyt=1:50-200 IF=1:50-200
  • Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
  • Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 靶点

      详见说明书

    • 级别

      1

    • 目录编号

      LM-0600R-FITC

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Anti-ADRA1A/FITC

    • 抗体名

      Anti-ADRA1A/FITC

    • 标记物

      FITC标记

    • 宿主

      Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,

    • 适应物种

      Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,

    • 免疫原

      详见说明书

    • 亚型

      IGg

    • 形态

      粉末、液体、冻干粉

    • 应用范围

      Flow-Cyt=1:50-200 IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul

    Anti-ADRA1A/FITC抗体
    英文名称 Anti-ADRA1A/FITC
    中文名称 Anti-ADRA1A/FITC抗体
    别    名 ADA1A_HUMAN; Adrenergic alpha 1A receptor; Adrenergic alpha 1C receptor; Adrenergic alpha 1D receptor; alpha 1 Adrenergic Receptor; Alpha 1A adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; ADRA1A; ADRA1C; Alpha 1A adrenoceptor; alpha-1A adrenergic receptor isoform 1; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; G protein coupled receptor; alpha-1A adrenoceptor; ADRA1L1; ALPHA1AAR.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    研究领域 细胞生物  神经生物学  细胞膜受体  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, 
    产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 51kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Alpha-1A adrenergic receptor
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008].

    Function:
    This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

    Subunit:
    Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

    Subcellular Location:
    Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

    Tissue Specificity:
    Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

    Post-translational modifications:
    C-terminal Ser or Thr residues may be phosphorylated.

    Similarity:
    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.

    Database links:

    Entrez Gene: 148 Human

    Entrez Gene: 11549 Mouse

    Entrez Gene: 29412 Rat

    Omim: 104221 Human

    SwissProt: P35348 Human

    SwissProt: P97718 Mouse

    SwissProt: P43140 Rat

    Unigene: 52931 Human

    Unigene: 709175 Human

    Unigene: 57064 Mouse

    Unigene: 9991 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    ADRA1能α1受体位于突触后,在血管平滑肌上,兴奋时可使血管收缩;
    alpha 1-adrenergic receptor有兴奋效应也有抑制效应。能受体又可分为α和β两种。alpha 受体与儿茶酚胺结合后,主要是兴奋平滑肌,如血管收缩、子宫收缩和瞳孔开张肌收缩等;但也有抑制作用,如使小肠平滑肌舒张。β受体又可分为β1和β2两个亚型.

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