Product overview Description Anti-BLNK rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human BLNK Reactivity Human, Mouse, Rat Content 0.6 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol BLNK Full name B-cell linker Synonyms bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65 Swissprot Q8WV28
Target Background This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
Applications Immunohistochemistry Predicted cell location: Cytoplasm or Cell membrane Positive control: Human thyroid cancer Recommended dilution: 40-200 Predicted cell location: Cytoplasm or Cell membrane Positive control: Human gastric cancer Recommended dilution: 40-200
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml224263(BLNK Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ml224263(BLNK Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)