Product overview Description Anti-TRAPPC4 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Full length fusion protein Reactivity Human, Mouse, Rat Content 0.4 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol TRAPPC4 Full name trafficking protein particle complex 4 Synonyms SBDN; TRS23; PTD009; CGI-104; HSPC172; SYNBINDIN Swissprot Q9Y296
Target Background TRAPPC4 (trafficking protein particle complex 4), also known as SBDN, TRS23, PTD009, CGI-104, HSPC172 (hematopoietic stem/progenitor cell protein 172) or SYNBINDIN, is a postsynaptic protein belonging to the TRAPPC4 subfamily of the TRAPP small subunits family of proteins. Expressed in neurons and localizing to the Golgi apparatus, TRAPPC4 is believed to be involved in vesicular transport from the endoplasmic reticulum (ER) to the Golgi, functioning as a component of the multisubunit transport protein particle (TRAPP) complex. Similar to other proteins involved in vesicular transport or synaptic function, TRAPPC4 contains a nonclassical PDZ domain, a TRAPPC1-like domain and a C-terminus that is similar to a short segment of RyR. Via its nonclassical PDZ domain, TRAPPC4 binds to the C-terminal EFYA motif of Syndecan-2, suggesting that TRAPPC4 may play an important role in dendritic spine morphogenesis through membrane-trafficking. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Applications Immunohistochemistry Predicted cell location: Nucleus and Cytoplasm Positive control: Human colorectal cancer Recommended dilution: 20-100
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ml223893(TRAPPC4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)