Product overview
Description Anti-HMGB2 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Synthetic peptide of human HMGB2
Reactivity Human, Mouse, Rat
Content 0.9 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol HMGB2
Full name high mobility group box 2
Synonyms HMG2
Swissprot P26583
Target Background
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.