Product overview
Description Anti-EGFR rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human EGFR
Reactivity Human, Mouse
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol EGFR
Full name epidermal growth factor receptor
Synonyms ERBB, HER1, mENA, ERBB1, PIG61
Swissprot P00533
Target Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.