- 询价
- gelatins
- JLC160228
- 上海
- 2025年07月13日
- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 克隆性：
多克隆
- 抗体名：
Anti-CXCR2 antibody
- 适应物种：
人/动物/植物
- 浓度：
0.4 mg/ml
- 保存条件：
-20°C
- 规格：
25 μl/100 μl/200 μl
Cat. No. JLC160228
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-CXCR2 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Synthetic peptide of human CXCR2
Reactivity Human
Content 0.4 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol CXCR2
Full name Chemokine (C-X-C motif) receptor 2
Synonyms CD182, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b
Swissprot P25025
Target Background
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
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