Anti-TGFBR1 antibody

Anti-TGFBR1 antibody

Cat. No.     JC261171
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-TGFBR1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human TGFBR1
Reactivity                 Human, Mouse, Rat
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 TGFBR1
Full name                 transforming growth factor, beta receptor 1
Synonyms    AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4
Swissprot    P36897

Target Background
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm, Cell membrane
Positive control: Human gasrtic cancer
Recommended dilution: 100-300    
            
The image on the left is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using ml261171(TGFBR1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)    

ELISA
Recommended dilution: 5000-20000