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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
FITC
- 适应物种:
Candida albicans
- 保质期:
6个月
- 抗原来源:
Candida albicans
- 目录编号:
P87020
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
/
- 浓度:
>95%,Protein G purified
- 靶点:
PRA1
- 抗体英文名:
PRA1 Antibody, FITC conjugated
- 抗体名:
PRA1 antibody;FBP1 antibody;CAALFM_C406980WA antibody;CaO19.10623 antibody;CaO19.3111 antibody;pH-regulated antigen PRA1 antibody;58 kDa fibrinogen-binding mannoprotein antibody
- 规格:
100μl/50μl
| 规格: | 100μl | 产品价格: | ¥1320.0 |
|---|---|---|---|
| 规格: | 50μl | 产品价格: | ¥880.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
功能
Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验ANTIBODY BINDING TO PROTEIN A AND PROTEIN G
. A physicochemical study f protein G, a molecule with unique immunoglobulin G-binding properties. J. Biol. Chem. 261:10240-10247. Harlow, E. and Lane, D. 1988. Antibodies. A laboratory manual. Cold Spring Harbor Laboratory. Kronvall, G., Seal, U. S
双特异抗体(Bispecific antibody)的简介和制作方法
、双特异抗体简介双特异抗体(Bispecific antibody)是含有两个不同配体结合位点的免疫球蛋白分子。自然状态下不存在双特异性抗体,只能通过特殊方法进行制备。以往双特异抗体的制备方法有化学交联法,杂合F(ab')2 分子法和鼠杂交瘤法等。化学交联法生产双特异抗体的异源性,批与批之间的不稳定性,以及抗体特异性易受某些修饰或不当连接而改变的特性,使得该法生产的双特异抗体不适于体内使用。以巯基交联蛋白酶消化片断F(ab')生产的双特异杂交分子,成分虽较均一,但费时费力,且产量很低。杂交瘤法生产
XBB.1.5 毒株的传播力为何这么强?北大曹云龙团队最新研究揭示相关机制
1 月 3 日,北京大学曹云龙团队及其合作者在预印本平台 bioRxiv,发表了题为 Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion 的文章,报道了关于 XBB.1.5 的最新研究成果。该研究表明,XBB.1.5 的传播性增强是由与 ACE2 的强结合和抗体逃逸共同促成的,该团队此前开发的中和抗体 SA55 对 XBB.1.5 仍有很强的活性
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