BARD1抗体BARD1兔多抗抗体BRCA1-associa
ted RING domain protein 1 antibody抗体BARD1 Antibody, FITC conjugated抗体- ￥880 - 1320
- CUSABIO
- CN
- CSB-PA860351LC01HU
- 2025年07月10日
- /
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant Human BRCA1-associated RING domain protein 1 protein (428-777AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
FITC
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q99728
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
/
- 浓度：
>95%,Protein G purified
- 靶点：
BARD1
- 抗体英文名：
BARD1 Antibody, FITC conjugated
- 抗体名：
BARD-1 antibody;Bard1 antibody;BARD1_HUMAN antibody;BRCA1 associated RING domain 1 antibody;BRCA1 associated RING domain gene 1 antibody;BRCA1 associated RING domain protein 1 antibody;BRCA1-associated RING domain protein 1 antibody
- 规格：
100μg/50μg
| 规格： | 100μg | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥880.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
功能
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验检索：Daza-Martin et al (2019). 'Isomerization of BRCA1-BARD1 promotes replication fork protection'. Nature. DOI: 10.1038/s41586-019-1363-4④ Science子刊：中大学者报道一种全新原理的m6A检测技术N6甲基腺嘌呤修饰，即m6A修饰，是真核生物mRNA上最丰富的修饰类型。近些年大量研究表明，m6A参与了mRNA的核心调控通路，如剪接、翻译、降解等，在肿瘤发生、神经发育、免疫
Comparative Protein Structure Modeling Using MODELLER
model in this range of sequence similarity is indicated by a comparison of a model for a domain in L2 protein from B. stearothermophilus with the actual structure ( 1rl2 ). View Image
Studies of the Ubiquitin Proteasome System
of E3 Enzymes Expressed in In Vitro Translation Systems Alternate Protocol 2: Determination of Ubiquitin Chain Variant Phenotype Basic Protocol 7: Chelation of Zinc from RING‐ and PHD‐Finger E3s Alternate Protocol 3: Inhibition of HECT Domain E
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