SET抗体SET兔多抗抗体chromatin remodel
ling factor antibody抗体SET Antibody, Biotin conjugated抗体- ￥880 - 1320
- CUSABIO
- CN
- CSB-PA875345LD01HU
- 2025年07月10日
- ELISA
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant Human Protein SET protein (147-235AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
Biotin
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q01105
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA
- 浓度：
>95%,Protein G purified
- 靶点：
SET
- 抗体英文名：
SET Antibody, Biotin conjugated
- 抗体名：
chromatin remodelling factor antibody
- 规格：
100μg/50μg
| 规格： | 100μg | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥880.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
功能
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验染色体免疫共沉淀（Chromatin immunoprecipitation，ChIP）方法程序
），剪切后的DNA小片段与结合蛋白结合（Isolate the chromatin. Shear DNA along with bound proteins into small fragments.） 第三步：用特异性 抗体 与DAN结合蛋白结合，用沉淀法分离复合体。反向交联操作释放出DNA，并消化蛋白质（Bind antibodies specific to the DNA-binding protein to isolate the complex
：分别是竞争性蛋白质结合分析法[3]、放射性免疫分析法[4]和薄层色谱法[5]。在80年代，放射性免疫分析法得到了广泛的应用和改进，由于这种方法采用放射性核素标记，应用范围受到一定限制，为了进一步提高检测的灵敏度和操作的安全性，进入90年代又陆续发明了各种酶标记法和化学发光法的竞争性ELISA检测试剂盒，这一类检测方法的根本原理都是基于抗体抗原的免疫反应，所有这些试剂盒中采用的抗体全部是兔抗血清或者是经过特异亲和提纯之后的抗cAMP或cGMP的兔多抗，毫无疑问，兔多抗在约四十年的cAMP，cGMP定量
Chromatin immunoprecipitation: optimization, quantitative analysis and data normalization
procedure Choosing antibodies Antibodies (Ab) are the most important factor for a successful ChIP experiment. It is crucial to choose an antibody carefully, especially when antibodies are raised against non-plant proteins. Papers reporting the use
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