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- 文献和实验
- 技术资料
- 免疫原:
Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA)
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
FITC
- 适应物种:
Human
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
Q9Y3S1
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
/
- 浓度:
>95%,Protein G purified
- 靶点:
WNK2
- 抗体英文名:
WNK2 Antibody, FITC conjugated
- 抗体名:
Serologically defined colon cancer antigen 43 antibody
- 规格:
100μg/50μg
| 规格: | 100μg | 产品价格: | ¥1320.0 |
|---|---|---|---|
| 规格: | 50μg | 产品价格: | ¥880.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
功能
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验【讨论】抗体和那些不能说的"秘密"-抗体选择的PASS标准 (请加精)
。 几年前很多科研工作者都使用一个公司生产的anti-hTERT antibody并发表了像Cancer Research等高影响因子的论文约20篇。但后来法国和中国的研究人员无意中发现这个抗体 实际上识别的是另外一个叫做nucleolin 的蛋白,并非hTERT,并将验证的工作发表在200 6年的Journal of Cell Science. 很多抗体公司几乎不去对那些同源性很近的蛋白,或者同一个蛋白家族的其他成员去做一 些抗体的交叉
。“我的免疫系统已经能够控制它了。” 参考文献 Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer 文献检索:DOI: 10.1056/NEJMoa1200690 BACKGROUND Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells
identifies distinct profiles defined by mutation status. 方法:methylated DNA immunoprecipitation (MeDIP) on Affymetrix promoter chips Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation
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