- ¥380 - 3800
- 百奥莱博
- M05770-KTH
- 北京
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
55
- 英文名：
RO4929097
- CAS号：
847925-91-1
- 保质期：
2年
- 供应商：
北京百奥莱博科技有限公司
- 保存条件：
-20℃，有效期2年，溶入溶剂后-20℃
- 规格：
1mL(10mM)|2mg|5mg|10mg|50mg|100mg
特别提示：包括γ secretase抑制剂(RO4929097)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
产品名称：γ secretase抑制剂(RO4929097)
英文名称：RO4929097
产品货号：M05770
产品规格：1mL(10mM)|2mg|5mg|10mg|50mg|100mg
RO4929097是一种γ secretase抑制剂，IC50值为4nM，能够抑制细胞内Aβ40的产生和Notch活性，EC50值分别为14nM和5nM。
注：本品仅可用于科研实验，严禁用于临床医疗及其他用途！
CAS号：847925-91-1
纯度：98.02%
分子式：C₂₂H₂₀F₅N₃O₃
分子量：469.4
结构式：
储存条件：-20℃，有效期2年，溶入溶剂后-20℃请尽量在一个月内使用。
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文献和实验A large body of evidence suggests a causative role of β-amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (reviewed in refs. 1 and 2 ). Aβ is neurotoxic and toxicity requires the formation of amyloid fibrils similar to those found in senile
Inhibition of α-Secretase by Zinc Metalloproteinase Inhibitors
The amyloid precursor protein (APP) is cleaved by at least three proteinases termed the α-, β-, and γ-secretases. Cleavage of APP at the N-terminus of the β-amyloid (Aβ) peptide by β-secretase and at the C-terminus by one or more γ-secretases
Using an Amyloid Precursor Protein (APP) Reporter to Characterize α-Secretase
- and γ-cleavages at the amino and carboxyl termini of Aβ produce amyloidogenic peptides; in contrast, α-cleavage within the Aβ domain destroys the amyloidogenic potential of APP. The proteases responsible for these cleavages have not been identified.
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