- ¥2980
- LMAI Bio
- LM-2047R-FITC
- 中国/美国/欧洲
- 2025年07月13日
- 详见说明书
- Human, Mouse, Rat,
- Human, Mouse, Rat,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-2047R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-CPT1A/FITC
- 抗体名：
Anti-CPT1A/FITC
- 标记物：
FITC标记
- 宿主：
Human, Mouse, Rat,
- 适应物种：
Human, Mouse, Rat,
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
详见说明书
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 英文名称 | Anti-CPT1A/FITC |
| 中文名称 | FITC标记的肉毒碱棕榈酰基转移酶1A抗体 |
| 别 名 | CPT 1; CPT1A; CPTI-L; CPT1-L; carnitine palmitoyl transferase 1; Carnitine O-palmitoyltransferase 1, liver isoform; CPT I; Carnitine palmitoyltransferase 1A; carnitine O-palmitoyltransferase 1, liver isoform isoform 1; CPT1A_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 激酶和磷酸酶 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 86kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CPT1A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The mitochondrial oxidation of long-chain fatty acids is nitiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. Subunit: Homohexamer and homotrimer. Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1. Also identified in complexes with ACSL1 and VDAC2 and VDAC3. Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein. Tissue Specificity: Strong expression in kidney and heart, and lower in liver and skeletal muscle. DISEASE: Carnitine palmitoyltransferase 1A deficiency (CPT1AD) [MIM:255120]: Rare autosomal recessive metabolic disorder of long-chain fatty acid oxidation characterized by severe episodes of hypoketotic hypoglycemia usually occurring after fasting or illness. Onset is in infancy or early childhood. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the carnitine/choline acetyltransferase family. Database links: Entrez Gene: 1374 Human Entrez Gene: 12894 Mouse Entrez Gene: 25757 Rat Omim: 600528 Human SwissProt: P50416 Human SwissProt: P97742 Mouse SwissProt: P32198 Rat Unigene: 503043 Human Unigene: 18522 Mouse Unigene: 2856 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验双重染色法免疫荧光组织化学染色步骤若在同一标本中有A和B两种抗原需要同时显示，A抗原的抗体用FITC标记，B抗原的抗体用TRITC标记，可采用以下染色方法：免疫荧光细胞化学双重染鱼法原代培养胚胎14天大鼠端脑细胞：在骨发生形态蛋白―{诱导下，乙酰胆碱转移酶(呈绿色荧光)和同源域蛋白Islet―1(呈红色荧光)共存于细胞质内(激光扫描共聚焦显微镜观察)1．一步双染色法先将两种荧光标{己抗体按适当比例混合(A+B)，按直接法进行染色。2．二步双染色法先用TRITC标记的A抗体进行免疫荧光染色，再用
蛋白，如 Src-家族激酶，被 N-肉豆蔻酰化。N-肉豆蔻酰基转移酶 (NMT) 专门促进 N-肉豆蔻酰化，并使用肉豆蔻酰 coa 作为底物将肉豆蔻酰基连接到 N-末端甘氨酸上。因为甲硫氨酸是所有真核生物蛋白质的 N-末端氨基酸，这个 PTM 在添加肉豆蔻酰基之前需要甲硫氨酸被上述 MAP 裂解；这是单个蛋白质上多个 PTM 的一个例子。③、S-palmitoylation（S-棕榈酰化）通过棕榈酰酰基转移酶 (PAT) 将来自棕榈酰基 CoA 的 C16 棕榈酰基添加到半胱氨酸残基的硫醇盐侧链。由于疏水
细胞膜的内侧,但在细胞凋亡的早期,PS可从细胞膜的内侧翻转到细胞膜的表面,暴露在细胞外环境中(图3).Annexin-V是一种分子量为35~36KD的Ca2+依赖性磷脂结合蛋白,能与PS高亲和力特异性结合.将Annexin-V进行荧光素(FITC、PE)或biotin标记,以标记了的Annexin-V作为荧光探针,利用流式细胞仪或荧光显微镜可检测细胞凋亡的发生...查看原文 线粒体膜势能的检测 线粒体在细胞凋亡的过程中起着枢纽作用,多种细胞凋亡刺激因子均可诱导不同的细胞
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