重组人PTPRN(蛋白酪氨酸磷酸酶受体型N)

特别提示：包括重组人PTPRN(蛋白酪氨酸磷酸酶受体型N)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人PTPRN(蛋白酪氨酸磷酸酶受体型N)
英文名称：Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N
产品货号：JN1779
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Arg576-Gln950在N端含有His标签。

PTPRN质量控制：＞95%(还原性SDS-PAGE)

PTPRN制剂：液体

PTPRN保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PTPRN：
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2.This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

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