Product overview Description Anti-ATXN3 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human ATXN3 Reactivity Human Content 0.7 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol ATXN3 Full name ataxin 3 Synonyms AT3; JOS; MJD; ATX3; MJD1; SCA3 Swissprot P54252
Target Background Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.