Anti-ACVR1C antibody

Anti-ACVR1C antibody

Cat. No.     JK221481      
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ACVR1C rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human ACVR1C
Reactivity                 Human, Mouse, Rat
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 ACVR1C
Full name                 activin A receptor, type IC
Synonyms    ALK7; ACVRLK7
Swissprot    Q8NER5

Target Background
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).