FITC标记的磷酸化周期素B1抗体

FITC标记的磷酸化周期素B1抗体

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  • ¥2980
  • LMAI Bio
  • LM-3733R-FITC
  • 中国/美国/欧洲
  • 2025年07月10日
  • IF=1:50-200
  • Human
  • Human
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 靶点

      详见说明书

    • 级别

      1

    • 目录编号

      LM-3733R-FITC

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Anti-Phospho-Cyclin B1 (Ser126)/FITC

    • 抗体名

      Anti-Phospho-Cyclin B1 (Ser126)/FITC

    • 标记物

      FITC标记

    • 宿主

      Human

    • 适应物种

      Human

    • 免疫原

      详见说明书

    • 亚型

      IGg

    • 形态

      粉末、液体、冻干粉

    • 应用范围

      IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul

    FITC标记的磷酸化周期素B1抗体
    英文名称 Anti-Phospho-Cyclin B1 (Ser126)/FITC
    中文名称 FITC标记的磷酸化周期素B1抗体
    别    名 Cyclin B1 (phospho S126); Cyclin B1 (phospho-Ser126); p-Cyclin B1 (S126); p-Cyclin B1 (Ser126); p-Cyclin B1 (phospho S126); CCNB 1; CCNB; CCNB1; CCNB1_HUMAN; G2 mitotic specific cyclin B1; G2/mitotic-specific cyclin-B1.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    产品类型 磷酸化抗体 
    研究领域 肿瘤  细胞生物  免疫学  细胞周期蛋白  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, 
    产品应用 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 48kDa
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Cyclin B1 around the phosphorylation site of Ser126
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008].

    Function:
    Essential for the control of the cell cycle at the G2/M (mitosis) transition.

    Subunit:
    Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization.

    Subcellular Location:
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.

    Post-translational modifications:
    Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases. 
    Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.

    Similarity:
    Belongs to the cyclin family. Cyclin AB subfamily.

    Database links:
    UniProtKB/Swiss-Prot: P14635.1

    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    主要出现在G2期。Cyclin B是细胞周期调节必不可少的条件。 细胞周期素B1是细胞周期调节因子,它的异常表达将导致细胞周期发生紊乱,致使肿瘤形成.

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