PTPN7(phospho S246); BPTP 4; BPTP4; Dual specificity phosphatase 1; Hematopoietic protein tyrosine phosphatase; LC PTP; LCPTP; LPTP; Protein tyrosine phoshatase non receptor type stress induced; Protein tyrosine phoshatase nonreceptor type stress induced; Protein tyrosine phosphatase LC PTP; Protein tyrosine phosphatase non receptor type 7; PTPN 7; PTPNI; Tyrosine protein phosphatase non receptor type 7; PTN7_HUMAN.
规格价格
100ul/1580元 购买 大包装/询价
说 明 书
100ul
产品类型
磷酸化抗体
研究领域
肿瘤 免疫学 信号转导 激酶和磷酸酶
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Mouse, Rat,
产品应用
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
40kDa
细胞定位
细胞浆
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated Synthesised phosphopeptide derived from human PTPN7 around the phosphorylation site of Ser246:CR(p-S)VK
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed
PubMed
产品介绍
background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Function: Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Subunit: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.
Subcellular Location: Cytoplasm.
Tissue Specificity: Expressed exclusively in thymus and spleen.
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 tyrosine-protein phosphatase domain.
SWISS: P35236
Gene ID: 5778
Database links:
Entrez Gene: 5778 Human
Entrez Gene: 320139 Mouse
Entrez Gene: 246781 Rat
Omim: 176889 Human
SwissProt: P35236 Human
SwissProt: Q8BUM3 Mouse
SwissProt: P49445 Rat
Unigene: 402773 Human
Unigene: 258388 Mouse
Unigene: 10160 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
Sample: Spleen (Mouse) Lysate at 40 ug Primary: Anti-phospho-PTPN7 (Ser246) (bs-5557R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 48 kD