L-Pyroglutamic acid L-焦谷氨酸

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.

CAS：98-79-3
中文别名：(S)-5-氧-2-吡*烷羧酸;(S)-(-)-2-*咯烷酮-5-羧酸;(S)-(-)-2-吡*烷酮-5-甲酸;5-羧基*咯*酮;
英文别名：L-Pyroglutamicacid;hydroxy-pyridin-3-yl-acetic acid;5 oxoproline;L-Proline, 5-oxo-;L-Pyroglutamic acid;
分子式：C5H7NO3
分子量：129.114
精确质量：129.043
Psa：66.4
Logp：-0.3216

MDL号：MFCD00005272

外观与性状：白色细晶体
密度：1.38 g/cm3
沸点：453.1ºC at 760 mmHg
熔点：160-163°C(lit.)
闪点：227.8ºC
折射率：-10 ° (C=5, H2O)
水溶解性：10-15 g/100 mL (20 ºC)
稳定性：Stable. Incompatible with bases, acids, strong oxidizing agents.
储存条件：Store at RT.