三(2-羧乙基)膦 盐酸盐

性质

Related Categories	Antioxidants and Reducing Agents for Protein Stabilization, Chemical Synthesis, Other Synthetic Reagents for Reduction, Reagents for Protein Stabilization, Reduction, 更多...
description	Protect from moisture
InChI Key	PBVAJRFEEOIAGW-UHFFFAOYSA-N
form	powder
color	white
solubility	H2O: 50 mg/mL
storage temp.	2-8°C

产品描述

Application

水溶性试剂，用于二硫化物的选择性还原。在质谱应用中比 DTT 更稳定。

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) may be employed as catalyst for the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides.1 It may be used as reducing agent for the reduction of various alkyl disulfides such as trans-4,5-dihydroxy-1,2-dithiane.^[4]

When basified, this water-soluble ligand allows for simple removal of ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture.^[2][3]

用于在水中进行的二硫化物选择性还原。^[1]

Caution

Storage conditions:protect from moisture.

包装

2, 10, 50 g in glass bottle

General description

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) is a non-volatile solid. It is a strong reducing agent.1^[4] It can be synthesized by the acid hydrolysis of tris(2-cyanoethyl)phosphine in refluxing aqueous HCl.1^[4] It has various biological applications such as in vitro and in vivo reduction of disulfide bonds in various peptides and proteins.1 TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II).^[5]