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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 靶点:
详见说明书
- 级别:
1
- 目录编号:
LM-5632R-FITC
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
Anti-phospho-SYN1(Ser62+Ser67)/FITC
- 抗体名:
Anti-phospho-SYN1(Ser62+Ser67)/FITC
- 标记物:
FITC标记
- 宿主:
Human, Mouse, Rat, Rabbit,
- 适应物种:
Human, Mouse, Rat, Rabbit,
- 免疫原:
详见说明书
- 亚型:
IGg
- 形态:
粉末、液体、冻干粉
- 应用范围:
IF=1:50-200
- 浓度:
1mg/ml
- 保存条件:
-20 °C
- 规格:
100ul
| 英文名称 | Anti-phospho-SYN1(Ser62+Ser67)/FITC |
| 中文名称 | FITC标记的磷酸化神经突触素1抗体 |
| 别 名 | Syn1(phospho S62/S67); Syn1(phospho Ser62/Ser67); Synapsin I (phospho S62 + S67); Synapsin I (phospho Ser62 + Ser67); Brain protein 4.1; SYN 1; SYN 1a; SYN 1b; SYN I; SYN1; SYN1a; SYN1b; Synapsin 1; Synapsin1; SynapsinI; Synapsin-1; SYNI; SYN1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 免疫学 神经生物学 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 85kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human SYN1 around the phosphorylation site of Ser62+Ser67 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. Subunit: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP. Subcellular Location: Cell junction, synapse. Golgi apparatus. Post-translational modifications: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles. DISEASE: Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders (XELBD) [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior. Similarity: Belongs to the synapsin family. Database links: Entrez Gene: 6853 Human Entrez Gene: 20964 Mouse Entrez Gene: 24949 Rat Omim: 313440 Human SwissProt: P17600 Human SwissProt: O88935 Mouse SwissProt: P09951 Rat Unigene: 225936 Human Unigene: 439844 Mouse Unigene: 9923 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验内腔可产生高强度的磁场,足以分离磁微粒标记的细胞,无需分离柱提供提供更高强度的磁场。由于磁微粒极小,不会影响靶细胞的流式分析结果,因此不需要去除。除了现有的定型产品外,客户可选择EasySep® PE、FITC或生物素分选系统与自己的PE、FITC或生物素—偶联的单抗相结合,来富集任何所需的细胞。如果您有自己的小鼠IgG1抗任何细胞的抗体, 也可以使用“Do-It-Yourself”试剂盒做成TAC,用来分选您想要的细胞。此外,还可以根据您的特殊需要,专门为您设计定做试剂盒。用于正选小鼠的细胞标记
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肌蛋白质组的影响。在蛋白质组学分析中,500 mg 组中最显著富集的通路是帕金蛋白介导的泛素和蛋白酶体系统,该通路包含泛素结合酶和蛋白酶体成分,是帕金蛋白介导的功能障碍线粒体和受损蛋白质降解所必需的;在 1000 mg 剂量组显著富集的通路包括与改善线粒体代谢在内的三羧酸循环、脂肪酸氧化、电子传递链和氧化磷酸化等。 图片来源:Cell Reports Medicine 最后,为了验证 UA 对线粒体自噬和线粒体功能相关蛋白的影响,他们对来自同一研究对象的肌肉活检样本进行了靶向 Western Blot
tissue,human testis tissue,human brain tissue IF:Hela,HepG2 另外有 HRP、FITC、Bintin 标记的多抗对应货号分别为: CSB-PA07179B0Rb、CSB-PA07179C0Rb、CSB-PA07179D0Rb 兔抗人淀粉样肽 beta A4 蛋白单克隆抗体 货号:CSB-MA0019501A0m 识别
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