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FITC标记的磷酸化神经突触素1抗体

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  • ¥2980
  • LMAI Bio
  • LM-5632R-FITC
  • 中国/美国/欧洲
  • 2025年07月12日
  • IF=1:50-200
  • Human, Mouse, Rat, Rabbit,
  • Human, Mouse, Rat, Rabbit,
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 靶点

      详见说明书

    • 级别

      1

    • 目录编号

      LM-5632R-FITC

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Anti-phospho-SYN1(Ser62+Ser67)/FITC

    • 抗体名

      Anti-phospho-SYN1(Ser62+Ser67)/FITC

    • 标记物

      FITC标记

    • 宿主

      Human, Mouse, Rat, Rabbit,

    • 适应物种

      Human, Mouse, Rat, Rabbit,

    • 免疫原

      详见说明书

    • 亚型

      IGg

    • 形态

      粉末、液体、冻干粉

    • 应用范围

      IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul

    FITC标记的磷酸化神经突触素1抗体
    英文名称 Anti-phospho-SYN1(Ser62+Ser67)/FITC
    中文名称 FITC标记的磷酸化神经突触素1抗体
    别    名 Syn1(phospho S62/S67); Syn1(phospho Ser62/Ser67); Synapsin I (phospho S62 + S67); Synapsin I (phospho Ser62 + Ser67); Brain protein 4.1; SYN 1; SYN 1a; SYN 1b; SYN I; SYN1; SYN1a; SYN1b; Synapsin 1; Synapsin1; SynapsinI; Synapsin-1; SYNI; SYN1_HUMAN.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    产品类型 磷酸化抗体 
    研究领域 免疫学  神经生物学  信号转导  细胞粘附分子  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Rabbit, 
    产品应用 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 85kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human SYN1 around the phosphorylation site of Ser62+Ser67
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

    Function:
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

    Subunit:
    Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP.

    Subcellular Location:
    Cell junction, synapse. Golgi apparatus.

    Post-translational modifications:
    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR. 
    Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.

    DISEASE:
    Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders (XELBD) [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.

    Similarity:
    Belongs to the synapsin family.

    Database links:

    Entrez Gene: 6853 Human

    Entrez Gene: 20964 Mouse

    Entrez Gene: 24949 Rat

    Omim: 313440 Human

    SwissProt: P17600 Human

    SwissProt: O88935 Mouse

    SwissProt: P09951 Rat

    Unigene: 225936 Human

    Unigene: 439844 Mouse

    Unigene: 9923 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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