重组人脑源性神经营养因子(BDNF)

特别提示：包括重组人脑源性神经营养因子(BDNF)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人脑源性神经营养因子(BDNF)
产品货号：MQ0114
产品规格：100μg

BDNF即脑源性神经营养因子(Brain derived neuroTrophic facTor)，是在脑内合成的一种蛋白质，它广泛分布于中枢神经系统内，在中枢神经系统发育过程中，对神经元的存活、分化、生长发育起重要作用,并能防止神经元受损伤死亡、改善神经元的病理状态、促进受损伤神经元再生及分化等生物效应，而且也是成熟的中枢及周围神经系统的神经元维持生存及正常生理功能所必需。
纯度：>98%
效价：2×103IU/mg
性状：本品为白色疏松体
保存温度：2-8℃
应用：
» 体外细胞培养
产品特性：
» GMP级生产环境，行业最高标准
» CHO稳定细胞株表达
» 无血清培养基生产
» GE Wave生物反应器培养

除了重组人脑源性神经营养因子(BDNF),，我公司还供应以下相关产品：



名称：重组人白介素IL-25(白细胞介素25)
货号：JN0407
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Tyr33-Gly177在C端含有His标签。

IL-25质量控制：＞95%(还原性SDS-PAGE)。

IL-25制剂：冻干品

IL-25保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-25复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-25：
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Human interleukin-17E (IL17E), also referred to as Interleukin-25 (IL25), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions, and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells.