重组人Cathepsin Z(组织蛋白酶Z)(溶酶体半胱氨酸

特别提示：包括重组人Cathepsin Z(组织蛋白酶Z)(溶酶体半胱氨酸蛋白酶)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人Cathepsin Z(组织蛋白酶Z)(溶酶体半胱氨酸蛋白酶)
英文名称：Recombinant Human Cathepsin Z
产品货号：JN1690
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gly24-Val303在C端含有His标签。

Cathepsin Z质量控制：＞95%(还原性SDS-PAGE)

Cathepsin Z制剂：液体

Cathepsin Z保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于Cathepsin Z：
Cathepsin Z is a lysosomal cysteine proteinase and belongs to the peptidase C1 family. Human Cathepsin Z contains a singnal sequence, a propeptide and a mature chain. It exhibits bothcarboxy-monopeptidase and carboxy-dipeptidase activities. In contrast to cathepsin B, it does not act as an endopeptidase. Cathepsin Z is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. It is expressed ubiquitously in cancer cell lines and primary tumors. Like other members of this family, Cathepsin Z may be involved in tumorigenesis.

除了重组人Cathepsin Z(组织蛋白酶Z)(溶酶体半胱氨酸蛋白酶),，我公司还供应以下相关产品：



名称：重组人趋化因子CCL3(MIP-1α)
货号：JN0292
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Ser24-Ala92表达纯化而来。

CCL3/MIP-1 alpha质量控制：＞95%(还原性SDS-PAGE)。

CCL3/MIP-1 alpha制剂：冻干品

CCL3/MIP-1 alpha保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

CCL3/MIP-1 alpha复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于CCL3/MIP-1 alpha：
Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.

名称：重组人ABCB5(ATP结合盒蛋白亚家族B成员5)
货号：JN0960
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Ile141-Val247在N端含Trx标签。

ABCB5质量控制：＞95%(还原性SDS-PAGE)

ABCB5制剂：冻干品

ABCB5保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

ABCB5复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于ABCB5：
ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.