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- 详细信息
- 技术资料
- 抗体名：
人CD28功能性抗体（T细胞激活扩增）
- 保质期：
一年
- 抗原来源：
其它
- 供应商：
上海研卉生物科技有限公司
- 库存：
现货
- 是否单克隆：
多克隆
- 抗体英文名：
人CD28功能性抗体（T细胞激活扩增）
- 保存条件：
RT
- 规格：
500ug
可以与TCR复合物结合，激活T细胞
SAFIRE(Sodium Azide Free Immensely Reduced Endotoxins)类产品是BioGems品牌下 的功能性抗体产品，经特殊工艺生产、纯化，具有诸多优点，可用于免疫细胞功能的激活、 阻断、中和研究，是肿瘤免疫研究的重要工具。
产品优势
极低的内毒素含量，低于0.01EU/μg蛋白
无diedan钠，适用于体内或体外实验
高蛋白纯度，适用于细胞治疗(CIK和CAR-T细胞制备)
Description
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Additional Information
|
Clone:
|
CD28.2
|
|
Format:
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SAFIRE Purified
|
|
Applications:
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FC, FA, IHC, IP
|
|
Reactivity:
|
Human
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|
Isotype:
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Mouse IgG1, kappa
|
| Research Interest: | Adaptive Immunity |
| Cell Type: | T Cells |
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Preparation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York Nunès, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., ... & Olive, D. (1993). CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.International immunology, 5(3), 311-315. Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., & Vaslin, B. (2007). FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. Journal of virology, 81(24), 13444-13455. |
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