产品名称
Anti-CENPB抗体
参阅全部 CENPB 一抗
描述
兔多克隆抗体to CENPB
宿主
Rabbit
经测试应用
适用于:WB,IHC-P,ICC/IFmore details
种属反应性
与反应:Mouse, Rat, Human
预测可用于:Sheep, Hamster
免疫原
Synthetic peptide conjugated to KLH derived from within residues 550 to the C-terminus of Human CENPB.
参阅Abcam的专有抗源政策(Peptide available asab28019.)
阳性对照
This antibody gave a positive signal in the following:HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateA431 (Human epithelial carcinoma cell line) Whole Cell LysateTestis (Mouse) Tissue Lysate - normal tissueOvary (Mouse) Tissue Lysate - normal tissuePC12 (Rat adrenal pheochromocytoma cell line) Whole Cell Lysate
应用
Ab评论
说明
WB
IHC-P
ICC/IF
功能
Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
Barra V et al. Phosphorylation of CENP-A on serine 7 does not control centromere function. Nat Commun10:175 (2019). Read more (PubMed: 30635586) »
Thakur J & Henikoff S Unexpected conformational variations of the human centromeric chromatin complex. Genes Dev32:20-25 (2018). Read more (PubMed: 29386331) »