- ￥1990
- peprotech
- 10312-25
- 中国
- 2025年11月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 抗体名：
小鼠CD28功能性抗体（T细胞激活扩增）
- 保质期：
一年
- 抗原来源：
其它
- 是否单克隆：
单克隆
- 抗体英文名：
小鼠CD28功能性抗体（T细胞激活扩增）
- 库存：
大量
- 供应商：
上海研卉生物科技有限公司
- 规格：
500ug
可以与TCR复合物结合，激活T细胞
SAFIRE(Sodium Azide Free Immensely Reduced Endotoxins)类产品是BioGems品牌下 的功能性抗体产品，经特殊工艺生产、纯化，具有诸多优点，可用于免疫细胞功能的激活、 阻断、中和研究，是肿瘤免疫研究的重要工具。
产品优势
极低的内毒素含量，低于0.01EU/μg蛋白
无diedan钠，适用于体内或体外实验
高蛋白纯度，适用于细胞治疗(CIK和CAR-T细胞制备)
Description
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.
The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.
Additional Information
|
Clone:
|
37.51
|
|
Format:
|
SAFIRE Purified
|
|
Applications:
|
FC, FA, IP
|
|
Reactivity:
|
Mouse
|
|
Isotype:
|
Golden Syrian Hamster IgG
|
| Research Interest: | Adaptive Immunity |
| Cell Type: | T Cells |
|
Preparation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
|
References:
|
Nandi, D., Gross, J. A., & Allison, J. P. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells. The Journal of Immunology, 152(7), 3361-3369. Gross, J. A., Callas, E. L. E. N. I., & Allison, J. P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse. The Journal of Immunology, 149(2), 380-388. Grossi, J. A., Raulet, D. H., & Allison, J. P. (1992). CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature, 356, 607-9. Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., & Podack, E. R. (1996). CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. The Journal of Immunology,157(10), 4347-4353. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
