DJ4; DnaJ; DNAJ B6; DnaJ homolog subfamily B member 6; DNAJB6; DNJB6_HUMAN; Heat shock protein J2; HHDJ1; HSJ-2; HSJ2; MRJ; MSJ-1; MSJ1.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
肿瘤 神经生物学 信号转导 细胞凋亡 细胞骨架 细胞外基质
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用
IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
36kDa
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human HSJ2/DNAJB6
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Reduces huntingtin aggregation associated with HD. Also reduces cellular toxicity and caspase-3 activity.
Tissue Specificity: Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
Similarity: Contains 1 J domain.
Database links:
Entrez Gene: 282215 Cow
Entrez Gene: 10049 Human
Entrez Gene: 23950 Mouse
Entrez Gene: 362293 Rat
Omim: 611332 Human
SwissProt: Q0III6 Cow
SwissProt: O75190 Human
SwissProt: O54946 Mouse
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications