重组人白介素27(IL-27)

特别提示：包括重组人白介素27(IL-27)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人白介素27(IL-27)
英文名称：Recombinant Human Interleukin-27
产品货号：JN1080
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Arg21-Lys229&Phe29-Pro243 ~ 在C端含有His标签。

IL-27质量控制：＞95%(还原性SDS-PAGE)

IL-27制剂：冻干品

IL-27保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IL-27复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IL-27：
IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. It is expressed on monocytes, endothelial cells and dendritic cells. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive CD4(+) T cells and plays a role in the early regulation of Th1 cells initiation which drives efficient adaptive immune response. IL-27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. IL-27 has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 protein may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. IL-27 has also an effect on cytokine production. It suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.

除了重组人白介素27(IL-27),，我公司还供应以下相关产品：
 

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JN0716	重组人超氧化物歧化酶2(SOD2)	10μg|50μg|500μg|1mg
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JN0932	重组人FIBP(FGFIBP)(酸性成纤维细胞生长因子胞内结合蛋白)	10μg|50μg|500μg|1mg
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JN0955	重组人NCK1	10μg|50μg|500μg|1mg
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JN1238	重组人核糖核酸酶T2(Rnase T2)	10μg|50μg|500μg|1mg
JN1277	重组人ABP1(阿米洛利结合蛋白1)	10μg|50μg|500μg|1mg
JN1316	重组小鼠CADM1(细胞粘附分子1)	10μg|50μg|500μg|1mg
JN1458	重组小鼠生长激素受体(GHR)(GHBP)	10μg|50μg|500μg|1mg
JN1776	重组大鼠Serpin A12(Vaspin)(脂肪特异性丝氨酸蛋白酶抑制剂)	10μg|50μg|500μg|1mg
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