重组小鼠Legumain(天冬酰胺肽链内切酶)(天冬氨酸内肽

特别提示：包括重组小鼠Legumain(天冬酰胺肽链内切酶)(天冬氨酸内肽酶)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠Legumain(天冬酰胺肽链内切酶)(天冬氨酸内肽酶)
英文名称：Recombinant Mouse Legumain/Asparaginyl Endopeptidase
产品货号：JN1806
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Val18-Tyr435在C端含有His标签。

Legumain质量控制：＞95%(还原性SDS-PAGE)

Legumain制剂：液体

Legumain保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于Legumain：
Mouse Legumain,also known as LGMN, is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly. LGMN has a strict specificity for hydrolysis of asparaginyl bonds. It can also cleave aspartyl bonds slowly, especially under acidic conditions. The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. It plays a role in the regulation of cell proliferation via its role in EGFR degradation. Legumain deficiency causes the accumulation of pro-Cathepsins B, H and L, another group of lysosomal cysteine proteases. Overexpression of Legumain in tumors is significant for invasion/metastasis. Mammalian legumain is inhibited by iodoacetamide and maleimides. Legumain activation appears to be autocatalytic and can be triggered by acidic pH.


除了重组小鼠Legumain(天冬酰胺肽链内切酶)(天冬氨酸内肽酶),，我公司还供应以下相关产品：



名称：重组人白介素IL-23(白细胞介素23)
货号：JN0403
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Arg20-Pro189&Ile23-Ser328在C端含有His标签。

IL-23质量控制：＞95%(还原性SDS-PAGE)。

IL-23制剂：冻干品

IL-23保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-23复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-23：
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.