重组人脱嘌呤脱嘧啶核酸内切酶1(APE)

特别提示：包括重组人脱嘌呤脱嘧啶核酸内切酶1(APE)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人脱嘌呤脱嘧啶核酸内切酶1(APE)
英文名称：Recombinant Human Apurinic-Apyrimidinic Endonuclease 1
产品货号：JN1907
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Pro2-Leu318表达纯化得来。

APE质量控制：＞95%(还原性SDS-PAGE)

APE制剂：液体

APE保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于APE：
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

除了重组人脱嘌呤脱嘧啶核酸内切酶1(APE),，我公司还供应以下相关产品：



名称：重组人趋化因子CCL18(PARC)
货号：JN0317
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Ala21-Ala89在N端含有His标签

CCL18/PARC质量控制：＞95%(还原性SDS-PAGE)。

CCL18/PARC制剂：冻干品

CCL18/PARC保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

CCL18/PARC复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于CCL18/PARC：
C-C Motif Chemokine 18 (CCL18) is secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL18 is expressed at high levels in the lung, lymph nodes, placenta, bone marrow, and dendritic cells. CCL18 is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. CCL18 may be involved in B-cell migration into B-cell follicles in lymph nodes. CCL18 attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.