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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 库存:
大量
- 供应商:
AssayPro
- 检测范围:
1 ng/ml
- 检测方法:
ELISA
- 应用:
血小板、富血小板血浆、细胞裂解液
- 样本:
50 μl
- 规格:
96 wells
人血小板膜糖蛋白IIb/IIIa酶联免疫试剂盒
血小板膜糖蛋白IIb/IIIa(GPIIb/IIIa,整合素αIIbβ3)是细胞膜受体整合素家族的一成员,整合素家族在血栓形成、血小板聚集、胚胎发生和细胞间黏附方面发挥重要作用。每一个整合素分子是由一条重链α和一条轻链β形成的分子量分别为140KDa和90KDa钙依赖性异二聚体(1)。GPIIb/IIIa可作为纤维蛋白原、纤维结合素、VWF分子、玻璃连接蛋白等的受体(2,3)。相毗邻血小板上该受体与二聚体形式的纤维蛋白原分子结合可引起血小板聚集。先天性GPIIb/IIIa受体缺陷可导致Glanzmann’s血小板无力症,此为一常染色体隐性遗传出血性疾病(4)。
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文献和实验Lectin-Induced Calcium Mobilization in Human Platelets: Use of Fluorescent Probes
, such as glycoprotein IIb–IIIa complex (GPIIb–IIIa) in controlling calcium homeostasis in platelets. GPIIb–IIIa is the platelet receptor for fibrinogen and other adhesive proteins and belongs to the integrin superfamily (4 ). It represents a high affinity binding site
Ligand-Binding Assays: Fibrinogen
The fibrinogen receptor on platelets is glycoprotein (GP) IIb/IIIa, also known as αIIb β3 . This receptor can bind to immobilized fibrinogen in its resting state. Binding to soluble fibrinogen, however, requires activation of the receptor
Antiplatelet, Anticoagulant, and Thrombolytic Drug Interactions
occlusion. The major pharmacological improvement in platelet efficacy has been the addition of glycoprotein IIb/IIIa inhibitors for PCIs. However, all GPIIb/IIIa inhibitors are associated with a risk of bleeding. Reduction of heparin doses has resulted
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