重组人白介素IL-25(白细胞介素25)

特别提示：包括重组人白介素IL-25(白细胞介素25)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人白介素IL-25(白细胞介素25)
英文名称：Recombinant Human Interleukin-25
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备，表达蛋白包含序列(Tyr33-Gly177)。

IL-25质量控制：＞95%(SEC-HPLC，还原性SDS-PAGE)

IL-25制剂：冻干品

IL-25保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-25复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-25：
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Human interleukin-17E (IL17E), also referred to as Interleukin-25 (IL25), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions, and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells. Human IL-17E cDNA encodes a 177 amino acid residues precursor protein with a putative 32 amino acid signal peptide. A second isoform of human IL-17E encoding a 161 amino acid precursor protein also exists.