Ganciclovir

HSV-tk/IL-2 Gene Therapy for Glioblastoma Multiforme

of intratumor injection of retroviral vector-producing cells, followed by intravenous ganciclovir administration. The primary endpoints of the study were the evaluation of the safety of the treatment and demonstration of transduction of tumor cells

Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis

product toward the prodrugs. The most widely investigated suicide genes and their respective prodrugs are the herpes simplex virus type I (HSV-1)-thymidine kinase (TK) with ganciclovir (GCV) and the Escherichia coli cytosine deaminase with 5-fluorocytosine

Oncolytic Herpes Simplex Virus Engineering and Preparation

divide in replicating cells make it fulfill a prerequisite criteria for oncolytic viruses. Other appealing features of HSV-1 as an oncolytic virus include its large, modifiable genome; its sensitivity to antiviral agents, such as ganciclovir; and its lack