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- 百奥莱博
- JN0815-OIR
- 北京
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
934
- 英文名：
Recombinant Human Tripeptidyl-Peptidase I
- 保质期：
6个月
- 供应商：
北京百奥莱博科技有限公司
- 保存条件：
收到货后请置于-20℃
特别提示：包括重组人三肽基肽酶1(TPP1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
产品名称：重组人三肽基肽酶1(TPP1)
英文名称：Recombinant Human Tripeptidyl-Peptidase I
产品规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ser20-Pro563在C端含有His标签。
TPP1质量控制：＞95%(还原性SDS-PAGE)
TPP1制剂：液体
TPP1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于TPP1：
Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).
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文献和实验Human Telomere POT1-TPP1 Complex and Its Role in Telomerase Activity Regulation
overhang at the ends of chromosomes in diverse eukaryotes. It is essential for chromosome end-protection and involved in telomere length regulation. TPP1 is a previously identified binding partner of POT1 that has been proposed to form part of a �
三句话读懂一篇 CNS：复旦大学研究表明，种花、种草有助预防多种疾病；打呼噜可能增加老年痴呆的风险
，美国匹兹堡 Dorothy P. 与 Richard P. Simmons 医学中心 Jonathan K. Alder 研究组与美国圣克鲁兹基因组研究所 Carol W. Greider 研究组联合在 Science 杂志发表研究论文 TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma。 该研究检测了来自 ICGC 联盟中黑色素瘤中端粒相关基因的体
Probing the Telomere Damage Response
at dysfunctional telomeres, achieved by the complete deletion of TRF2 or by expressing dominant negative mutant TPP1ΔRD , can be detected by their association with γ-H2AX and 53BP1 forming “telomere dysfunction induced foci (TIFs).” Induction of TIFs at telomeres
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