重组小鼠GITR(TNFRSF18)北京厂家现货

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博主要从事生物试剂的生产和销*(代"售")，产品线涵盖重组小鼠GITR(TNFRSF18)北京厂家现货在内的分子生物学试剂产品，还包括PCR及荧光定量PCR、核酸提取试剂盒类、样本核酸保护试剂、核酸提取、克隆与转化、蛋白纯化、蛋白检测、免疫组化、细胞凋亡与抗体等。

名称：重组小鼠GITR(TNFRSF18)北京厂家现货
品牌：百奥莱博
产地：国产|进口
编号：JN0463
英文名：Recombinant Mouse Glucocorticoid Induced TNF Receptor Family Related Gene
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ser22-His153在C端含有Fc标签和His标签

GITR/TNFRSF18质量控制：＞95%(还原性SDS-PAGE)

GITR/TNFRSF18制剂：冻干品

GITR/TNFRSF18保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

GITR/TNFRSF18复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于GITR/TNFRSF18：
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is asecreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

除重组小鼠GITR(TNFRSF18)北京厂家现货外，我公司正在打折促销以下产品：

·重组人泛素样蛋白(ISG15)
编号：JN0883
英文名称：Recombinant Human Interferon-stimulated Gene 15
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Gly2-Gly157在C端含有His标签。

ISG15质量控制：＞95%(还原性SDS-PAGE)

ISG15制剂：液体

ISG15保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于ISG15：
Ubiquitin-Like Protein ISG15 is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha/beta stimulation or microbial challenge.The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation.ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. Upon interferon treatment, ISG15 can be detected in both free and conjugated forms, and is secreted from monocytes and lymphocytes where it can function as a cytokine. In the cell, ISG15 co-localizes with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.


重组小鼠GITR(TNFRSF18)北京厂家现货关键词：重组小鼠GITR蛋白,JN0463,重组GITR,重组小鼠TNFRSF18


·重组人蝶呤4α甲醇胺脱水酶1(PCBD1)
编号：JN2016
英文名称：Recombinant Human Pterin-4-alpha-Carbinolamine Dehydratase
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Ala2-Thr104在N端含有His标签。

PCBD1质量控制：＞95%(还原性SDS-PAGE)

PCBD1制剂：液体

PCBD1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PCBD1：
Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.


重组小鼠GITR(TNFRSF18)北京厂家现货关键词：重组小鼠GITR蛋白,JN0463,重组GITR,重组小鼠TNFRSF18

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