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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
trans-Resveratrol; SRT501
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
501-36-0
- 规格：
10 mM * 1 mL/200 mg/500 mg/1 g/5 g/10 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 200 mg | 产品价格： | ￥500.0 |
| 规格： | 500 mg | 产品价格： | ￥1050.0 |
| 规格： | 1 g | 产品价格： | ￥1400.0 |
| 规格： | 5 g | 产品价格： | ￥2500.0 |
| 规格： | 10 g | 产品价格： | ￥3250.0 |
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Resveratrol
CAS No. : 501-36-0
MCE 国际站：Resveratrol
产品活性：Resveratrol (trans-Resveratrol; SRT501) 是一种天然多酚，具有抗氧化，抗炎，保护心脏和抗癌的特性。 它的靶点广泛，如 mTOR、JAK、β-amyloid、Adenylyl cyclase、IKKβ、DNA polymerase。Resveratrol 也是一种特异性的 SIRT1 活化剂。Resveratrol 是有效的孕烷 X 受体 (PXR) 抑制剂。Resveratrol 是一种 Nrf2 激活剂，在小鼠模型中可以改善衰老相关的进行性肾损伤。Resveratrol 作用于内皮细胞促进 NO 产生。
研究领域：NF-κB | Autophagy | Cell Cycle/DNA Damage | Epigenetics | Apoptosis | Anti-infection
作用靶点：IKK | Autophagy | Mitophagy | Sirtuin | Apoptosis | Bacterial | Fungal | Antibiotic | Keap1-Nrf2
In Vitro: Resveratrol (trans-Resveratrol; SRT501) is one of the numerous polyphenolic compounds found in several vegetal sources In the vast majority of cases, Resveratrol displays inhibitory/activatory effects in the micromolar range, which is potentially attainable pharmacologically, although targets with affinities in the nanomolar range have also been reported.
MCF-7 cells are plated in DME-F12 medium supplemented with 5% FBS in the presence of increasing concentrations of Resveratrol. Control cells are treated with the same volume of vehicle only (0.1% ethanol). Resveratrol inhibits the growth of MCF-7 cells in a dose-dependent fashion. Addition of 10 μM Resveratrol results in an 82% inhibition of MCF-7 cell growth after 6 days while at 1 μM, only a 10% inhibition is observed. The cells treated with 10 μM Resveratrol have a doubling time of 60 hr whereas control cells doubled every 30 hr. Trypan blue exclusion assay shows that at concentrations of 10 μM or lower, Resveratrol does not affect cell viability (90% viable cells) whereas at 100 μM, only 50% of the cells are viable after 6 days of Resveratrol treatment. Moreover, MCF-7 cells do not undergo apoptosis after incubation with Resveratrol at concentration of 10 μM as determined by ApoAlert Annexin V Apoptosis kit.
Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling.
In Vivo: The average tumor volume is reduced by treatment with Resveratrol (trans-Resveratrol; SRT501) at a dose of 50 mg/kg body weight (195.5±124.8 mm3; P<0.05) or 100 mg/kg body weight (81.7±70.5 mm3; P<0.001) compare with the vehicle-treated animals (315±94 mm3). There is a good correlation between the tumor volume and the tumor mass.
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文献和实验（Resveratrol）：无色针状结晶，mp256-257℃，216℃升华，易溶于乙醚、氯仿、甲醇、乙醇、丙酮等。 7．白藜芦醇葡萄糖苷（polydotinpeceid）：无色颗粒状结晶，双熔点分别为130-140℃225～226℃，易溶于甲醇、乙醇、丙酮、热水，可溶于乙酸乙酯、可溶于碳酸钠和氢氧化钠水溶液中，稍溶于冷水，难溶于乙醚。 8．β-谷甾醇 9．鞣质：属缩合鞣质，可溶于醇及水，不溶于苯、乙醚、氯仿等。 另外。虎杖叶、茎中含少量羟基蒽醌类化合物、有机酸、槲皮
以下是primer3自动得到的引物，请高手指导，在线等。大写字母为外显子，小写的为内含子。 谢谢！！！！ OLIGO start len tm gc% any 3' seq LEFT PRIMER 501 20 61.99 55.00 6.00 2.00 AGCCTGGCCAACGTGTCTAT RIGHT PRIMER 1026 22 59.42 36.36 2.00 0.00 tcgttgctgtttttctgttttc SEQUENCE SIZE: 1250
11.2(10.0-80.0)1.59±0.341.67±0.38(0.50-2.65)135±12.0128±14.0(78.0-155)19.2±4.9317.6±4.36(13.1-29.5)2.65±0.882.62±0.87(1.00-4.30)146±1.15141±1.40(138-155)5.75±0.206.40±0.16(3.60-6.80)101±1.45105±1.22(92.0-122)24.2±3.1522.8±3.20(16.2-31.8)4.82±1.055.06±
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