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- 英文名：
Recombinant Murine IL-17A
- 供应商：
上海研卉生物科技
- 规格：
25ug
Recombinant Murine IL-17A
Product Details
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Murine IL-17A is a 30.0 kDa, disulfide-linked homodimer of two 133 amino acid, polypeptide chains.
Source: E.coli
Synonyms: IL-17, CTLA-8
AA Sequence (monomer): AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Measured by its ability to induce IL-6 production by NIH 3T3 cells.
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
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| Lindemann, M J | Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. | The Journal of Biological Chemistry; 283(20) pg14100-8 | 16 May 2008 | 18348982 Show Usages |
| Stritesky, G L | IL-23 promotes maintenance but not commitment to the Th17 lineage. | Journal of immunology (Baltimore, Md. : 1950); 181(9) pg5948-55 | 1 Nov 2008 | 18941183 Show Usages |
| Hou, W | Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. | The Journal of Experimental Medicine; 206(2) pg313-28 | 16 Feb 2009 | 19204109 Show Usages |
| Perona-Wright, G | A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. | Journal of immunology (Baltimore, Md. : 1950); 182(5) pg2808-15 | 1 Mar 2009 | 19234175 Show Usages |
| von Vietinghoff, S | IL-17A controls IL-17F production and maintains blood neutrophil counts in mice. | Journal of immunology (Baltimore, Md. : 1950); 183(2) pg865-73 | 15 Jul 2009 | 19542376 Show Usages |
| Wang, J | Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes. | Journal of immunology (Baltimore, Md. : 1950); 183(2) pg1384-92 | 15 Jul 2009 | 19570823 Show Usages |
| Zhang, S | Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. | PLoS Neglected Tropical Diseases; 4(3) pge648 | 30 Mar 2010 | 20361029 Show Usages |
| He, Y | The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent. | BMC Immunology; 11 pg28 | 10 Jun 2010 | 20537152 Show Usages |
| Takeuchi, H | Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β. | PLoS ONE; 6(1) pge16089 | 7 Jan 2011 | 21249211 Show Usages |
| Mi, S | Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. | Journal of immunology (Baltimore, Md. : 1950); 187(6) pg3003-14 | 15 Sep 2011 | 21841134 Show Usages |
| Bian, Z | Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions. | Journal of immunology (Baltimore, Md. : 1950); 188(2) pg844-53 | 15 Jan 2012 | 22156344 Show Usages |
| Stange, J | IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology. | Journal of immunology (Baltimore, Md. : 1950); 188(5) pg2410-8 | 1 Mar 2012 | 22266282 Show Usages |
| Paust, H | Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. | Kidney International; 82(1) pg72-83 | 0 Jul 2012 | 22495297 Show Usages |
| Holoshitz, J | An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity. | Journal of immunology (Baltimore, Md. : 1950); 190(1) pg48-57 | 1 Jan 2013 | 23180817 Show Usages |
| Bian, Z | CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis. | Journal of immunology (Baltimore, Md. : 1950); 190(1) pg411-7 | 1 Jan 2013 | 23203922 Show Usages |
| Koning, J J | Mesenchymal stem cells are mobilized from the bone marrow during inflammation. | Frontiers in Immunology; 4 pg49 | 0 2013 | 23459632 Show Usages |
| Paiva, R S | Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. | Proceedings of the National Academy of Sciences of the United States of America; 110(16) pg6494-9 | 16 Apr 2013 | 23576744 Show Usages |
| Jie, Z | Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection. | Journal of immunology (Baltimore, Md. : 1950); 192(7) pg3289-300 | 1 Apr 2014 | 24600029 Show Usages |
| Harada, M | Temporal expression of growth factors triggered by epiregulin regulates inflammation development. | Journal of immunology (Baltimore, Md. : 1950); 194(3) pg1039-46 | 1 Feb 2015 | 25556244 Show Usages |
| Somma, D | CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17. | Journal of immunology (Baltimore, Md. : 1950); 194(7) pg3286-94 | 1 Apr 2015 | 25710910 Show Usages |
| Pacios, S | Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B. | Scientific Reports; 5 pg16694 | 15 Dec 2015 | 26666569 Show Usages |
| Ono, T | IL-17-producing γδ T cells enhance bone regeneration. | Nature Communications; 7 pg10928 | 11 Mar 2016 | 26965320 Show Usages |
| Ulivieri, C | The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis. | Journal of immunology (Baltimore, Md. : 1950); 197(2) pg480-90 | 15 Jul 2016 | 27288534 Show Usages |
| Bhattacharya, N | Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer. | Immunity; 45(3) pg641-655 | 20 Sep 2016 | 27590114 Show Usages |
| Matsumura, K | Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis. | Journal of immunology (Baltimore, Md. : 1950); 197(8) pg3233-3244 | 15 Oct 2016 | 27605010 Show Usages |
| Niu, S | Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice. | Journal of immunology (Baltimore, Md. : 1950); 197(8) pg3293-3301 | 15 Oct 2016 | 27619992 Show Usages |
| Subbarayal, B | IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity. | Journal of immunology (Baltimore, Md. : 1950); 197(9) pg3464-3470 | 1 Nov 2016 | 27655846 Show Usages |
| Maruyama, K | Bone-protective Functions of Netrin 1 Protein. | The Journal of Biological Chemistry; 291(46) pg23854-23868 | 11 Nov 2016 | 27681594 Show Usages |
| Yang, Z | Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation. | Scientific Reports; 7(1) pg7918 | 11 Aug 2017 | 28801611 Show Usages |
| Tusi, B K | Population snapshots predict early haematopoietic and erythroid hierarchies. | Nature; 555(7694) pg54-60 | 1 Mar 2018 | 29466336 Show Usages |
| Rothberg, J L | Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. | Cell Discovery; 4 pg21 | 0 2018 | 29736258 Show Usages |
| Mulati, K | VISTA expressed in tumour cells regulates T cell function. | British Journal of Cancer; 120(1) pg115-127 | 0 Jan 2019 | 30382166 Show Usages |
| Åhsberg, J | Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner. | The Journal of Biological Chemistry; 288(46) pg33449-61 | 15 Nov 2013 | 24078629 Show Usages |
| Åhsberg, J | Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner. | The Journal of Biological Chemistry; 288(46) pg33449-61 | 15 Nov 2013 | 24078629 Show Usages |
| Dahlgren, M W | Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. | Immunity; 50(3) pg707-722.e6 | 19 Mar 2019 | 30824323 Show Usages |
| Stanisavljević, S | Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats. | Scientific Reports; 9(1) pg918 | 29 Jan 2019 | 30696913 Show Usages |
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文献和实验人白细胞介素-17A（IL-17A）酶联免疫分析（ELISA）
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