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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Recombinant Human IL-17B
- 供应商：
上海研卉生物科技
- 规格：
25µg
IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T cells, and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage. Recombinant Human IL-17B is a 36.6 kDa non-disulfide-linked homodimer of two 161 amino acid polypeptide chains.
Source: E.coli
Synonyms: IL20, NIRF
AA Sequence (monomer): MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng.
Note: Results may vary with PBMC donors.
Note:
1mg will be provided as 2x500μg.
| Silacci, M | Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency. | The Journal of Biological Chemistry; 289(20) pg14392-8 | 16 May 2014 | 24692552 Show Usages |
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