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- 200-34
- 2025年10月11日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Recombinant Human IL-34
- 供应商：
上海研卉生物科技有限公司
- 规格：
10µg
IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
Source: HEK293 cells
Synonyms: Interleukin-34, C16orf77
AA Sequence (monomer): NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Measured by its ability to induce secretion of MCP-1 from PBMCs.
Note:
1mg will be provided as 2x500μg.
Size
2µg
10µg
50µg
100µg
250µg
500µg
1mg
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Hwang, S | Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis. | Arthritis research & therapy; 14(1) pgR14 | 20 Jan 2012 | 22264405 Show Usages |
| Abud, E M | iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. | Neuron; 94(2) pg278-293.e9 | 19 Apr 2017 | 28426964 Show Usages |
| Haenseler, W | A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. | Stem Cell Reports; 8(6) pg1727-1742 | 6 Jun 2017 | 28591653 Show Usages |
| Brownjohn, P W | Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. | Stem Cell Reports; 10(4) pg1294-1307 | 10 Apr 2018 | 29606617 Show Usages |
| Nzou, G | Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. | Scientific Reports; 8(1) pg7413 | 9 May 2018 | 29743549 Show Usages |
| Lin, Y | APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. | Neuron; 98(6) pg1141-1154.e7 | 27 Jun 2018 | 29861287 Show Usages |
| Kveler, K | Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed. | Nature Biotechnology; 36(7) pg651-659 | 0 Aug 2018 | 29912209 Show Usages |
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文献和实验Transmigration of Human CD34+ Cells
to understand the mechanisms responsible for their homing and/or mobilization. In this chapter, we will describe the methodology utilized in our laboratory to evaluate migration of human CD34+ cells that contain HSC.
Construction of Recombinant Human Cytomegalovirus
The use of reverse genetics to generate recombinant viruses allows the researcher to investigate the exact functional significance of particular viral genes during the virus life cycle, by means of their deletion or modification in the viral
Generation of TransgenicT Cells from Human CD34+Cord Blood Cells
, more committed CD34+ progenitors expressing CD38, and lineage markers like CD7 or IL-7R can generate T cells in the thymus (1 ). Cord blood, fetal liver, bone marrow, and peripheral blood CD34+ cells can generate T cells. These progenitors differ
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