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- 200-34
- 2025年10月11日
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- 详细信息
- 技术资料
- 英文名：
Recombinant Human IL-34
- 供应商：
上海研卉生物科技有限公司
- 规格：
10µg
IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
Source: HEK293 cells
Synonyms: Interleukin-34, C16orf77
AA Sequence (monomer): NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Measured by its ability to induce secretion of MCP-1 from PBMCs.
Note:
1mg will be provided as 2x500μg.
Size
2µg
10µg
50µg
100µg
250µg
500µg
1mg
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Hwang, S | Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis. | Arthritis research & therapy; 14(1) pgR14 | 20 Jan 2012 | 22264405 Show Usages |
| Abud, E M | iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. | Neuron; 94(2) pg278-293.e9 | 19 Apr 2017 | 28426964 Show Usages |
| Haenseler, W | A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. | Stem Cell Reports; 8(6) pg1727-1742 | 6 Jun 2017 | 28591653 Show Usages |
| Brownjohn, P W | Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. | Stem Cell Reports; 10(4) pg1294-1307 | 10 Apr 2018 | 29606617 Show Usages |
| Nzou, G | Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. | Scientific Reports; 8(1) pg7413 | 9 May 2018 | 29743549 Show Usages |
| Lin, Y | APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. | Neuron; 98(6) pg1141-1154.e7 | 27 Jun 2018 | 29861287 Show Usages |
| Kveler, K | Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed. | Nature Biotechnology; 36(7) pg651-659 | 0 Aug 2018 | 29912209 Show Usages |
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