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- 详细信息
- 技术资料
- 英文名：
Recombinant Human EPO
- 库存：
3W
- 供应商：
研卉生物
- 规格：
50ug
Recombinant Human EPO
Product Details
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. PeproTech’s Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.
Source: CHO cells
Synonyms: Erythropoietin, Epoetin
AA Sequence: APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR
Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml.
Calculated Molecular Weight: 18.4 kDa
Accession Number: P01588
Gene ID: 2056
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
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| Pavel-Dinu, M | Gene correction for SCID-X1 in long-term hematopoietic stem cells. | Nature Communications; 10(1) pg1634 | 9 Apr 2019 | 30967552 Show Usages |
| Kuppers, D a | N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis. | Nature Communications; 10(1) pg4596 | 10 Oct 2019 | 31601799 Show Usages |
| Du, W | Fancb deficiency impairs hematopoietic stem cell function. | Scientific Reports; 5 pg18127 | 11 Dec 2015 | 26658157 Show Usages |
| Xie, X | Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. | Scientific Reports; 5 pg18115 | 18 Dec 2015 | 26681454 Show Usages |
| MacLean, G A | Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells. | Scientific Reports; 8(1) pg8001 | 22 May 2018 | 29789608 Show Usages |
| Saxena, S | Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation. | Stem Cell Reports; 6(5) pg692-703 | 10 May 2016 | 27117782 Show Usages |
| Wen, W | Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors. | Stem Cell Reports; 6(6) pg873-884 | 14 Jun 2016 | 27161365 Show Usages |
| Kauts, M | Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells. | Stem Cell Reports; 11(4) pg1009-1020 | 9 Oct 2018 | 30197119 Show Usages |
| Chennupati, V | Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. | The Journal of Clinical Investigation; 128(4) pg1597-1614 | 2 Apr 2018 | 29408805 Show Usages |
| Zhang, P | Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. | The Journal of Clinical Investigation; 128(12) pg5383-5398 | 3 Dec 2018 | 30226831 Show Usages |
| Xia, P | WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. | The Journal of Experimental Medicine; 211(10) pg2119-34 | 22 Sep 2014 | 25225459 Show Usages |
| Xia, P | Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages. | The Journal of Experimental Medicine; 212(13) pg2305-21 | 14 Dec 2015 | 26573296 Show Usages |
| Balmer, M L | Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. | Journal of immunology (Baltimore, Md. : 1950); 193(10) pg5273-83 | 15 Nov 2014 | 25305320 Show Usages |
| Mumau, M D | Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1. | Journal of immunology (Baltimore, Md. : 1950); 200(3) pg1078-1087 | 1 Feb 2018 | 29282309 Show Usages |
| Schenke-Layland, K | Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. | Stem cells (Dayton, Ohio); 26(6) pg1537-46 | 0 Jun 2008 | 18450826 Show Usages |
| Gao, R | Bmi1 promotes erythroid development through regulating ribosome biogenesis. | Stem cells (Dayton, Ohio); 33(3) pg925-38 | 0 Mar 2015 | 25385494 Show Usages |
| Zeng, Y | Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. | Stem cells (Dayton, Ohio); 33(5) pg1630-41 | 0 May 2015 | 25586960 Show Usages |
| Forester, C M | Revealing nascent proteomics in signaling pathways and cell differentiation. | Proceedings of the National Academy of Sciences of the United States of America; 115(10) pg2353-2358 | 6 Mar 2018 | 29467287 Show Usages |
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