重组人组织因子TF，Tissue Factor
其他名称:
TF, TF1, Coagulation factor III, factor III, F3, Thromboplastin, CD142
Description:
Tissue factor is a transmembrane glycoprotein of the cytokine receptor superfamily that acts as a receptor forcoagulation factor VII (fVII) to trigger initiation of the coagulation cascade in response to vascular injury. Expression of tissuefactor occurs constitutively within most extravascular and perivascular cells and at high levels within critical organs and tissue.Tissue factor is not normally expressed freely on the surface of circulating blood cells due to its pro-coagulant effect, but is insteadstored on the surface of mononuclear and endothelial cells in microparticles that can shed into circulation in response to vascularinjury, pro-inflammatory cytokines, or microbial ligands. Tissue factor can also be shed into circulation by cancer cells where itsexpression in a number of cancer types has been linked to tumor progression, metastatic potential, thrombosis, and angiogenesis.Expression of tissue factor has been shown to be inducible by select cytokines in a number of cell types, including IL-1β and TNF-αin vascular endothelial cells and macrophages, and TNF-α, IL-6, and FGF-Basic in monocytes, among others. PeproTech’ssCHOcell-derived Recombinant Human Tissue Factor is a glycoprotein homodimer comprised of the 214-amino-acid length monomercontaining a C-terminal His-Tag. It has a calculated molecular weight of approximately 24.4 kDa, and as a result of glycosylation, Recombinant Human Tissue Factor migrates with an apparent molecular mass of approximately 45-55 kDa by SDS-PAGE gel,under reducing conditions.
AA Sequence:
SGTTNTVAAY NLTWKSTNFK TILEWEPKPV NQVYTVQIST KSGDWKSKCF YTTDTECDLT DEIVKDVKQT YLARVFSYPA GNVESTGSAG EPLYENSPEF TPYLETNLGQ PTIQSFEQVG TKVNVTVEDE RTLVRRNNTF LSLRDVFGKD LIYTLYYWKS SSSGKKTAKT NTNEFLIDVD KGENYCFSVQ AVIPSRTVNR KSTDSPHHHH HHHH
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验
技术资料