Recombinant Human CLDN18.1 (N-

Recombinant Human CLDN18.1 (N-8His)科研用

Recombinant Human CLDN18.1 (N-8His) (CR54)

产品说明(Description)

Recombinant Human CLDN18.1 is produced by our E.coli expression system and the target gene encoding Asp28-Leu76 is expressed with a 8His tag at the N-terminus.

Accession #: P56856

Known as: Claudin-18; CLDN18

制剂(Formulation)

Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 25mM NaCl, 10% Glycerol, pH 8.0.

质量控制(Quality Control)

Purity: Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

运输(Shipping)

The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.

背景(Background)

Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Claudin（CLDN）是正常组织紧密连接蛋白，具有4个跨膜结构域，其家族包含至少24个成员，其中Claudin 18有Claudin 18.1和Claudin 18.2两种异构体。Claudin 18.2其表达严格限于胃粘膜已分化的上皮细胞中。现有数据表明，Claudin 18.2（Uniprot No：P56856-2）与Claudin 18.1（Uniprot No：P56856-1）只有第一个胞外区有8个氨基酸的差异，人和小鼠中相对保守，筛选特异性的Claudin 18.2抗体难度也是较大。

注意：FOR RESEARCH USE ONLY仅限科学研究用，不得用于临床！