- ￥1033
- abgent
- AD80004
- USA
- 2025年07月14日
- IHC
- Rabbit Monoclonal Antibody
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- 详细信息
- 询价记录
- 技术资料
- 抗体名：
CD3免疫组化抗体，Ready-to-use
- 抗体英文名：
CD3 Antibody
- 应用范围：
IHC
- 宿主：
Rabbit Monoclonal Antibody
- 供应商：
上海研卉生物科技有限公司
- 保质期：
一年
- 适应物种：
人
- 库存：
大量
- 是否单克隆：
0
- 保存条件：
低温
- 规格：
6ml
CD3免疫组化抗体，Ready-to-use
Application
|
IHC |
|---|---|
| Primary Accession | P04234 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Clone Names | 230B2F6 |
| Gene ID | 915 |
|---|---|
| Gene Name | CD3D |
| Other Names | T-cell surface glycoprotein CD3 delta chain, T-cell receptor T3 delta chain, CD3d, CD3D, T3D |
| Dilution | IHC~~Ready-to-use |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Synonyms | T3D |
|---|---|
| Function | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells |
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CD3免疫组化抗体，Ready-to-use
￥1033
