- ￥1475
- Santa/Abnova/Abcam
- AD80067
- USA
- 2025年07月15日
- IHC
- Mouse Monoclonal
- 人
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- 详细信息
- 技术资料
- 抗体名：
CD8免疫组化抗体，Ready-to-use
- 抗体英文名：
CD8 Antibody Mouse Monoclonal
- 应用范围：
IHC
- 宿主：
Mouse Monoclonal
- 供应商：
上海研卉生物科技有限公司
- 库存：
大量
- 适应物种：
人
- 保质期：
一年
- 是否单克隆：
0
- 保存条件：
低温
- 规格：
6ml
CD8免疫组化抗体，Ready-to-use
CD8 Antibody
Mouse Monoclonal Antibody (Mab)
Application
|
IHC |
|---|---|
| Primary Accession | P01732 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 457F6F8 |
| Gene ID | 925 |
|---|---|
| Gene Name | CD8A |
| Other Names | T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL |
| Dilution | IHC~~Ready-to-use |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Synonyms | MAL |
|---|---|
| Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK- cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |
| Cellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. |
| Tissue Location | CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homo-dimers Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation. |
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CD8免疫组化抗体，Ready-to-use
￥1475
