- ¥170 - 2500
- 百奥莱博
- JN1833-KXR
- 北京
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
312
- 英文名：
Recombinant Human 5-Nucleotidase
- 保质期：
6个月
- 供应商：
北京百奥莱博科技有限公司
- 保存条件：
收到货后请置于-20℃
| 货号 | 规格 | 产品价格 |
|---|---|---|
| JN1833-BMN | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
| JN1833-RVK | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
| JN1833-XYQ | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
| JN1833-SMN | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
| JN1833-ZDA | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
| JN1833-STU | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
| JN1833-CBY | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
| JN1833-XPG | 10μg|50μg|500μg|1mg | ¥1880 - 2880 |
特别提示：包括重组人CD73(5-Nucleotidase)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
产品名称：重组人CD73(5-Nucleotidase)
英文名称：Recombinant Human 5-Nucleotidase
产品规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Trp27-Lys547在C端含有His标签。
CD73/5-Nucleotidase质量控制：＞95%(还原性SDS-PAGE)
CD73/5-Nucleotidase制剂：液体
CD73/5-Nucleotidase保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于CD73/5-Nucleotidase：
CD73 is a glycosyl phosphatidylinositol (GPI) anchored membrane protein that belongs to the 5-nucleotidase family. CD73 is an ecto 5Nucleotidase expressed by most cell types. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. CD73 is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. CD73 is a lymphocyte maturation marker that has functions independent of its catalytic activity. CD73 is also a regulator of leukocyte extravasation, a function that requires its 5Nucleotidase activity. Defects in NT5E are the cause of calcification of joints and arteries (CAJA). The recombinant CD73 lacking GPI anchor is secreted as a monomer.
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文献和实验CD73 分子 CD73 常用单克隆抗体或代号： 7G2.2.11,AD- 2 主要表达细胞： Bsub,Tsub,En [B] 分子质量(kDa)和结构： p69(GPI连接） 功 能： 5’-核苷酸外切酶,T细胞活化 CD73 Aka ecto-5-nucleotidase, PI-linked Catalyses dephosphorylation of purine
Isolation of a Membrane-Bound Enzyme, 5-Nucleotidase
Membrane enzymes may be peripheral or integral proteins. The attachment of peripheral enzymes is mediated mainly by association with other membrane proteins and consists primarily of hydrophilic, electrostatic interactions. Integral membrane
一年内两次叫停！康方CD73单抗又“悬”了，PD-1的黄金搭档还香吗？
’-Nucleotidase)，是由NT5E基因编码的一种细胞表面，是催化AMP形成胞外腺苷的主要酶 [1]。人CD73的基因位于染色体6q14-921。CD73的进化相当保守，人CD73的cDNA序列与鼠的cDNA序列有86%的同源性 [2]。人CD73前体蛋白由574个氨基酸残基组成。CD73分子N末端第1-26位氨基酸残基及C末端第550-574位氨基酸残基被剪切后，第27-549位氨基酸残基序列即为成熟CD73，形成1个分子量约为70 kDa亚单位，由两个亚单位构成具有生物活性的同质二聚体，亚基间通过非共价键连接
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