- ¥860 - 1580
- LMAI Bio
- LM-33040M
- 进口/国产
- 2025年11月27日
- WB=1:500-1000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-33040M
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Lamin B
- 抗体名：
核纤层蛋白B单克隆抗体(细胞核膜标志物)
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat,
- 免疫原：
Recombinant human Lamin B Protein:
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-1000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul
| 英文名称 | Lamin B |
| 中文名称 | 核纤层蛋白B单克隆抗体(细胞核膜标志物) |
| 别 名 | lamin B1; LMB1; LMN; LMN2; LMNB 1; LMNB; LMNB1; MGC111419; LMNB1_HUMAN; Lamin-B1. |
| 规格价格 | 50ul/860元 购买 100ul/1580元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul |
| 产品类型 | 内参抗体 |
| 研究领域 | 细胞生物 染色质和核信号 信号转导 细胞凋亡 细胞类型标志物 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 克 隆 号 | 9C11 |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | WB=1:500-1000 ELISA=1:500-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 64kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Recombinant human Lamin B Protein: |
| 亚 型 | IgG1 |
| 纯化方法 | affinity purified by Protein G |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]. Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin Subunit: Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2. Subcellular Location: Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side Post-translational modifications: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. DISEASE: Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis. Similarity: Belongs to the intermediate filament family. SWISS: P20700 Gene ID: 4001 Database links: Entrez Gene: 396223 Chicken Entrez Gene: 4001 Human Entrez Gene: 16906 Mouse Entrez Gene: 116685 Rat Omim: 150340 Human SwissProt: P14731 Chicken SwissProt: P20700 Human SwissProt: P14733 Mouse SwissProt: P70615 Rat Unigene: 89497 Human Unigene: 4105 Mouse Unigene: 11362 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample:MOLT-4 Cell (Human) Lysate at 40 ug Primary: Anti-LaminB(bsm-33040M)at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 64kD Observed band size: 64kD |
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文献和实验的早期诊断和治疗对 AD 的防治具有重要的临床意义。 二、AD 诊断的常见蛋白标志物 对于 AD 的早期诊断和疾病风险评估，生物标志物的检测是一项重要指标。关于 AD 发病机制的各种假设导致了许多不同类型的生物标志物的发展，其中更是以 Aβ 寡/多肽、tau 蛋白和载脂蛋白 E（ApoE）的衍生物为主。 1、淀粉样蛋白 β（Aβ） Aβ 肽是由淀粉样前体蛋白（APP）经过 β 和 γ 分泌酶相关的一系列剪切事件后产生的，通常由 38‒42 个氨基酸组成，分子量约 4 kDa。Aβ
加重具有非常重要的临床价值。近几年来，一些新的具有高度特异性和敏感性的心肌标志物检测指标已较为普遍地用于临床实验室诊断，如肌钙蛋白T或I、肌红蛋白、肌酸激酶同工酶（isoenzymeofcreatinekinasecontainingMandBsubunits，CK-MB）、B型尿钠肽、超敏C反应蛋白（C-reactiveprotein，CRP）等。对这些新的心肌标志物的正确应用为临床准确诊断、鉴别诊断和判断治疗效果起到了革命性的作用。由于这些新的指标是近几年才开始在国内逐步普及应用，因此掌握
影响因素1.肿瘤标志物具有特异性和非特异性的双重特点。2.各种肿瘤特性的不同，如肿瘤的分期、大小、定位、组织来源及转移趋向等的不同。3.各种抗体的不同，如多克隆抗体、单克隆抗体、抗体决定簇和抗体亲和性等的不同。 4.各种检测系统的不同，如检测原理、标记物、实验条件、检测技术、检测仪器和检测敏感度等的不同。5.检验人员的专业水平和技术经验、以及实验室条件和实验的可靠性等的差异。（1）甲胎蛋白（AFP） 分子量约为7万的糖蛋白，由590个氨基酸组成，存在于胎儿肝脏和卵黄囊。 主要用于原发
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