- ¥780 - 2200
- LMAI Bio
- LM-2040R
- 进口/国产
- 2026年04月20日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-2040R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Atrial natriuretic factor
- 抗体名：
心房钠尿因子/心钠素/心房利钠肽抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
- 免疫原：
KLH conjugated synthetic peptide derived from human ANP:81-153/153
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | Atrial natriuretic factor |
| 中文名称 | 心房钠尿因子/心钠素/心房利钠肽抗体 |
| 别 名 | Prepronatriodilatin; ANF_HUMAN; Cardiodilatin; ANF; Atrial natriuretic factor; CDD ANF; CDP; PND; Prepronatriodilatin; Nppa; Natriuretic peptides A; Atrial natriuretic peptide; CDD-ANF; ANP. |
 |
Specific References (2) | bs-2040R has been referenced in 2 publications. [IF=1.70] Straub, Rainer H., et al. "Increased extracellular water measured by bioimpedance and by increased serum levels of atrial natriuretic peptide in RA patients—signs of volume overload." Clinical Rheumatology (2016): 1-11 IHC-F ; Human. PubMed:27112146 [IF=0.00] Malinowski, Nadezhda. Erhöhtes extrazelluläres Wasser gemessen durch Bioimpedanz und erhöhter Serumspiegel von atrialem natriuretischen Peptid bei rheumatoider Arthritis–Anzeichen von Volumenüberlastung. Diss. 2015. IHC-F ; Human. PubMed:000 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 心血管 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 3/17kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANP:81-153/153 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]. Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Subunit: Interacts with NPR1. Subcellular Location: Secreted. Post-translational modifications: Cleaved by CORIN upon secretion to produce the functional hormone. DISEASE: Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the natriuretic peptide family. SWISS: P01160 Gene ID: 4878 Database links: Entrez Gene: 4878 Human Entrez Gene: 608289 Dog Entrez Gene: 230899 Mouse Omim: 108780 Human SwissProt: P07499 Dog SwissProt: P01160 Human SwissProt: P05125 Mouse Unigene: 75640 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 心钠素（心房利尿钠肽）：心钠素主要是由心房分泌的一种含有28个氨基酸并由二硫键结合的一环形肽分子，具有强大的利钠、利尿、扩血管等作用。使血管舒张，外周阻力降低；使每博输出量变少，心率减慢；肾排水排钠增多；导致体内细胞外液量减少。 心钠素主要来源于心肌纤维，但脑、肾、肺、肾上腺等器官、组织也能表达，但产生及分泌的方式有一定差异。 |
| 产品图片 |  Sample: Heart (Mouse) Lysate at 40 ug Heart (Rat) Lysate at 40 ug Primary: Anti-Atrial natriuretic factor (bs-2040R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 3/17 kD Observed band size: 15 kD  Paraformaldehyde-fixed, paraffin embedded (Rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Atrial natriuretic factor) Polyclonal Antibody, Unconjugated (bs-2040R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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文献和实验can occur between AT receptors and receptors for atrial natriuretic factor (ANF) (2 ), bradykinin (3 ), catecholamines (4 ), adrenocorticotropin releasing hormone (5 ), vasopressin (6 ), and dopamine (7 ). Ang II is also found to indirectly modulate
尿多肽（atrial natriuretic polypeptide），简称心钠素，有很强的利尿、排钠、扩张血管和降血压作用。近年研究还证明，心肌还能分泌其它多种生物活性物质，如与心钠素作用相似的脑钠素、抗心律失常肽和内源性洋地黄素（又称内洋地黄素）。心肌细胞还具有合成肾素和血管紧张素的能力，对促进心肌细胞生长，增强心肌收缩力等有重要作用。 在心房肌和心室肌之间，有由致密结缔组织组成的支持性结构，构成心脏的支架，也是心肌和心瓣膜的附着处，称心骨骼（cardiac skeleton
Induction and Analysis of Cardiac Hypertrophy in Transgenic Animal Models
. After periods between 3 and 21 d, parameters such as cardiac hemodynamics, morphologic alterations, and expression of marker genes (e.g., the gene for atrial natriuretic peptide) are analyzed in genetically modified animals and compared with controls elucidating
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